Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Steroid metabolism with intestinal microorganisms

H Groh1, K Schade, C Hörhold-Schubert

  • 1Jenaer Beutenberg-Institute, Wissenschaftler-Integrations-Programm der KAI e.V. Berlin, Jena, Germany.

Journal of Basic Microbiology
|January 1, 1993
PubMed
Summary

The intestine acts as an endocrine organ due to anaerobic microbes metabolizing steroids, bile acids, and hormones. Further research is needed to understand these steroid transformations and their biological impacts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

THE RAGWEED SITUATION IN EASTERN CANADA IN RELATION TO HAY FEVER.

Canadian Medical Association journal·2010
Same author

Collaborative model: nonoperative spleen and liver management.

Journal of trauma nursing : the official journal of the Society of Trauma Nurses·2006
Same author

Isotretinoin alleviates renal damage in rat chronic glomerulonephritis.

Kidney international·2001
Same author

Intracranial malposition of nasopharyngeal airway.

The Journal of trauma·2000
Same author

Preparation of 3-ketodesogestrel metabolites by microbial transformation and chemical synthesis.

Steroids·1997
Same author

Hydroxylation of the native brassinosteroids 24-epicastasterone and 24-epibrassinolide by the fungus Cunninghamella echinulata.

Steroids·1993

Area of Science:

  • Microbiology
  • Endocrinology
  • Gastroenterology

Background:

  • The intestine harbors anaerobic microorganisms involved in the metabolism of sterols, bile acids, and steroid hormones.
  • These metabolic activities are linked to the enterohepatic circulation, suggesting the intestine's role as an endocrine-active site.
  • Understanding these microbial transformations is crucial for comprehending steroid hormone homeostasis.

Purpose of the Study:

  • To review the transformations of steroids by anaerobic intestinal bacteria.
  • To discuss the physiological and pathophysiological significance of these steroid transformations.
  • To recommend further research into the elucidation of these reactions and their biological responses.

Main Methods:

  • Literature review of studies on anaerobic intestinal bacteria and steroid metabolism.

Related Experiment Videos

  • Analysis of existing data on the enterohepatic circulation of steroids.
  • Synthesis of information regarding the biological roles of microbial steroid transformations.

    • Main Results:

    • Anaerobic intestinal bacteria significantly transform various steroids, including bile acids and steroid hormones.
    • These transformations influence the pool of biologically active steroids within the host.
    • The intestine's role as an endocrine-active site is supported by extensive microbial steroid metabolism.

    Conclusions:

    • The metabolic activities of intestinal anaerobic microorganisms contribute to the endocrine function of the intestine.
    • Further investigation is warranted to fully elucidate the enzymatic pathways and biological consequences of microbial steroid transformations.
    • Understanding these processes may reveal new therapeutic targets for steroid-related disorders.