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Updated: Aug 12, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Overexpression of cyclin D1 in mouse skin carcinogenesis

A B Bianchi1, S M Fischer, A I Robles

  • 1Department of Carcinogenesis, University of Texas, M.D. Anderson Cancer Center, Smithville 78957.

Oncogene
|May 1, 1993
PubMed

Insights

Altered cyclin D1 expression is critical in mouse skin cancer. Overexpression in advanced tumors suggests a role in autonomous growth during tumor progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cyclin D1, a G1 cyclin, is implicated in various cancers.
  • Its role in different tumor progression stages requires investigation in a defined model.

Purpose of the Study:

  • To investigate the role of cyclin D1 alteration in mouse skin carcinogenesis.
  • To determine if cyclin D1 overexpression correlates with tumor progression stages.

Main Methods:

  • Mapping of the Cyl1 gene to mouse chromosome 7.
  • Analysis of Cyl1 transcript levels in different stages of skin tumor development.

Main Results:

  • Cyl1 gene mapped to mouse chromosome 7.
  • Dramatic overexpression of Cyl1 observed in skin squamous cell carcinomas (SCC).
  • Early papillomas showed basal Cyl1 levels; advanced papillomas exhibited overexpression.

Conclusions:

  • Altered cyclin D1 expression is critical in mouse skin carcinogenesis.
  • Cyclin D1 overexpression may contribute to autonomous growth in papillomas.
  • This mouse model is valuable for studying multistep tumor progression.

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