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Burn induced cardiac dysfunction is reduced by pentoxifylline

W G Vaughan1, J W Horton, D J White

  • 1Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9031.

Surgery, Gynecology & Obstetrics
|May 1, 1993
PubMed
Summary

Pentoxifylline (PTX) treatment improved cardiac function in rats after severe burn injury. PTX mitigated myocardial dysfunction, suggesting its potential as an adjunctive therapy for thermal injury patients.

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Area of Science:

  • Cardiovascular Physiology
  • Burn Injury Research
  • Pharmacology

Background:

  • Thermal injury causes significant cardiac dysfunction, impairing contractility and relaxation.
  • Myocardial defects persist post-resuscitation and are linked to inflammatory mediators and neutrophils.
  • Pentoxifylline (PTX) is known to modulate neutrophil-mediated inflammatory effects.

Purpose of the Study:

  • To investigate the efficacy of Pentoxifylline (PTX) in improving cardiac dysfunction following burn injury.
  • To assess the impact of PTX on myocardial contractility and relaxation parameters in a rat model.

Main Methods:

  • Isolated, coronary-perfused rat hearts were used to evaluate cardiac function.
  • Animals underwent full-thickness scald burns (40% body surface area) or sham procedures.

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  • Burned rats received PTX (50 mg/kg) at 30 minutes, 6 hours, and 20 hours post-insult; control groups included untreated burned rats and sham-burned rats.

    • Main Results:

    • Burn injury significantly decreased left ventricular pressure (LVP) and maximal rate of LVP change (+/-dP/dt max).
    • PTX treatment in burned rats resulted in significantly higher LVP and +/-dP/dt max compared to untreated burned rats.
    • Hearts from PTX-treated burned rats exhibited LV function curves comparable to sham-burned hearts.

    Conclusions:

    • Pentoxifylline (PTX) effectively attenuates cardiac dysfunction induced by thermal injury in rats.
    • These findings suggest a potential therapeutic role for PTX as an adjunctive treatment following burn injuries.