Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Soluble proteins: size, shape and function

D S Goodsell1, A J Olson

  • 1Molecular Biology Institute, University of California, Los Angeles 90024.

Trends in Biochemical Sciences
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mesoscope: A Web-based Tool for Mesoscale Data Integration and Curation.

MolVa : Workshop on Molecular Graphics and Visual Analysis of Molecular Data 2020·2023
Same author

Cuttlefish: Color Mapping for Dynamic Multi-Scale Visualizations.

Computer graphics forum : journal of the European Association for Computer Graphics·2019
Same author

Tomato bushy stunt virus at 2.9 A resolution.

Nature·2009
Same author

Analysis of large-scale sequencing of small RNAs.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing·2008
Same author

The molecular perspective: antibodies.

The oncologist·2001
Same author

Recognition templates for predicting adenylate-binding sites in proteins.

Journal of molecular biology·2001
Same journal

Peptideins: Navigating the gray zone of the proteome.

Trends in biochemical sciences·2026
Same journal

A metabolon channels nicotine biosynthesis.

Trends in biochemical sciences·2026
Same journal

Better call chaperone.

Trends in biochemical sciences·2026
Same journal

Biochemistry at scale: Seeing both the forest and the trees.

Trends in biochemical sciences·2026
Same journal

Voices across Asia and Oceania: Biochemistry across borders.

Trends in biochemical sciences·2026
Same journal

Metabolic control of RNA splicing by polyamines.

Trends in biochemical sciences·2026
See all related articles

Cells build large, multi-part proteins (oligomeric proteins) for complex functions. A review of protein structures reveals insights into why cells construct these large protein assemblies.

Area of Science:

  • Structural biology
  • Biochemistry
  • Molecular biology

Background:

  • Proteins are essential macromolecules performing diverse cellular functions.
  • The size and quaternary structure (oligomeric state) of proteins are critical for their biological roles.
  • Understanding the principles governing protein size and oligomerization is fundamental to cell biology.

Purpose of the Study:

  • To investigate the structural basis for large protein size.
  • To explore the reasons behind the cellular construction of oligomeric proteins.
  • To gain new insights into protein architecture and function.

Main Methods:

  • Visual survey of protein structures.
  • Analysis of data from the Protein Data Bank (PDB).

Related Experiment Videos

Main Results:

  • Identification of structural patterns associated with large protein complexes.
  • Correlation between protein size/oligomeric state and functional requirements.
  • New perspectives on the evolutionary and functional drivers of protein architecture.

Conclusions:

  • Protein size and oligomerization are driven by functional demands and structural constraints.
  • The Protein Data Bank provides a valuable resource for understanding fundamental protein properties.
  • This study offers a new framework for analyzing protein assembly and complexity.