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Updated: Jul 20, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Are pathohistological studies helpful in the clinical differential diagnosis of chronic arthritis?]
J Flechtenmacher1, K Rohe, H Cotta
1Orthopädische Universitäts-Klinik Heidelberg.
Abstract:
We have evaluated the diagnostic and therapeutic consequences of histopathological examinations of knee synovium from 216 patients with chronic arthropathies. We were able to differentiate between non-rheumatic etiologies, such as tuberculous arthritis, villonodular synovitis, crystal arthropathies and chondromatosis. This resulted in the establishment of a diagnosis and often a guide to therapy as well. It is rarely possible however to conclusively differentiate among the different inflammatory rheumatic diseases or osteo-arthroses by the histopathology of the joint lesions seen.
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