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Isradipine: a profile in essential hypertension
1Department of Medicine, University of Gothenburg, Sweden.
Acta Anaesthesiologica Scandinavica. Supplementum
|January 1, 1993
Summary
Isradipine, a vascular-selective calcium antagonist, effectively treats hypertension with minimal cardiac effects. This drug is well-tolerated, showing potential anti-atherosclerotic and neuroprotective benefits in preclinical studies.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
Background:
- Isradipine is a dihydropyridine-derived calcium antagonist.
- It exhibits significant vascular selectivity with potent vasodilating action.
- Isradipine demonstrates minimal cardiac effects in clinical practice.
Purpose of the Study:
- To review the efficacy and tolerability of isradipine in treating arterial hypertension.
- To explore the potential anti-atherosclerotic and neuroprotective effects of isradipine.
Main Methods:
- Clinical data review on isradipine's use in hypertension.
- Analysis of preclinical studies investigating isradipine's effects on atherosclerosis and stroke models.
Main Results:
- Isradipine is effective as monotherapy or in combination for hypertension.
- The drug is well-tolerated, with rare side effects like flushing and ankle edema.
- Animal studies indicate anti-atherosclerotic and brain-protective properties relevant to antihypertensive doses.
Conclusions:
- Isradipine is a valuable antihypertensive agent with a favorable safety profile.
- Potential anti-atherosclerotic and neuroprotective effects warrant further human investigation for clinical significance.