Related Experiment Video
Updated: Sep 28, 2026

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
Published on: May 26, 2015
Detection of atherosclerotic lesions in the aorta by transesophageal echocardiography
P Nihoyannopoulos1, J Joshi, G Athanasopoulos
1Department of Medicine, Hammersmith Hospital, London, United Kingdom.
Insights
Transesophageal echocardiography can identify thoracic aorta atherosclerosis, a marker for widespread vascular disease and systemic emboli. This imaging technique may help monitor plaque changes with interventions.
Area of Science:
- Cardiovascular Imaging
- Vascular Biology
- Diagnostic Echocardiography
Background:
- Atherosclerosis in the thoracic aorta is a significant risk factor for systemic embolization.
- Identifying thoracic aortic plaques can indicate diffuse atherosclerotic disease.
Purpose of the Study:
- To assess the prevalence of thoracic aorta atherosclerosis using transesophageal echocardiography.
- To correlate thoracic aorta plaque presence with systemic embolization and other vascular diseases.
Main Methods:
- Prospective transesophageal echocardiographic (TEE) studies were conducted in 152 patients over 40 years old.
- Patients were evaluated for atherosclerotic lesions in the thoracic aorta.
- Data on systemic embolization, coronary artery disease, carotid artery disease, and peripheral vascular disease were collected.
Main Results:
- Twenty-nine percent of patients had thoracic aorta atherosclerotic lesions.
- Thoracic aorta plaques were strongly associated with coronary artery disease (78%), carotid artery disease (88%), and peripheral vascular disease.
- Patients with systemic emboli (28%) were more likely to have thoracic aorta plaques (48%) compared to those without emboli (22%, p < 0.001).
Conclusions:
- Transesophageal echocardiography effectively identifies atherosclerotic plaques in the thoracic aorta.
- Thoracic aorta plaques serve as a marker for diffuse atherosclerosis and increased risk of systemic emboli.
- TEE may be valuable for serial monitoring of atherosclerotic plaque progression or regression during therapeutic interventions.
Abstract:
Transesophageal echocardiographic studies were prospectively performed in 152 consecutive patients older than age 40 years referred to the echocardiography laboratory to assess the prevalence of atherosclerosis in the thoracic aorta and relate this to a history of systemic embolization. Forty-four patients (29%) had at least 1 atherosclerotic lesion in the thoracic aorta. This was associated with a higher prevalence of coronary artery disease (78% of all patients with coronary artery disease), carotid artery disease (88% of all patients with carotid artery disease) and peripheral vascular disease (all symptomatic patients). Forty-two of all patients (28%) had systemic emboli, 20 (48%) of whom had at least 1 atheromatous lesion in the thoracic aorta. Conversely, only 24 of 110 patients (22%) without previous systemic emboli had atheromatous lesions (p < 0.001). It is concluded that atherosclerotic lesions in the thoracic aorta can readily be identified with transesophageal echocardiography. The detection of atherosclerotic plaques of the aorta represents a marker of diffuse atherosclerotic disease, often associated with carotid, coronary and peripheral vascular disease and with the occurrence of systemic emboli. Transesophageal echocardiography may be used serially to investigate whether dietary or pharmacologic maneuvers, or both, can shrink established atherosclerotic plaques in the thoracic aorta.
Related Concept Videos
Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Acute Coronary Syndrome III: Diagnostic Studies
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Aneurysm II: Clinical Manifestations and Diagnostic Studies

