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Related Experiment Videos

Ketoconazole administration in hypercortisolemic depression

O M Wolkowitz1, V I Reus, F Manfredi

  • 1Department of Psychiatry, University of California, San Francisco.

The American Journal of Psychiatry
|May 1, 1993
PubMed
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Ketoconazole treatment reduced cortisol levels and depression symptoms in hypercortisolemic patients. This suggests antiglucocorticoid drugs may help study depression linked to high cortisol.

Area of Science:

  • Endocrinology
  • Psychiatry
  • Pharmacology

Background:

  • Major depression is linked to hypercortisolemia.
  • The role of cortisol in depression requires further investigation.

Purpose of the Study:

  • To evaluate ketoconazole's effect on hypercortisolemic depressed patients.
  • To assess antiglucocorticoid agents as tools for studying depression.

Main Methods:

  • Administered ketoconazole to 10 hypercortisolemic depressed patients for up to 6 weeks.
  • Monitored serum cortisol levels and depression ratings.

Main Results:

  • Seven patients completed the study.
  • Significant decreases in serum cortisol and depression ratings were observed.

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  • Ketoconazole was associated with these improvements.

    • Conclusions:

    • Antiglucocorticoid agents like ketoconazole show potential in treating depression associated with hypercortisolemia.
    • Further research is warranted to explore antiglucocorticoid mechanisms in major depression.