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Updated: Aug 18, 2026
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 29, 2010
The effectiveness of ovarian cancer screening. A decision analysis model
M M Schapira1, D B Matchar, M J Young
1Medical College of Wisconsin, Milwaukee.
Objective:
To estimate the effectiveness of ovarian cancer screening with CA 125 and transvaginal sonography.
Design:
Decision analysis was used to examine the no-screen compared with the screen strategy.
Setting:
Estimates of cancer incidence, survival, and life expectancy were derived from population-based data and clinical series.
Subjects:
A cohort of 40-year-old women of all races and residing in the United States.
Interventions:
A one-time screening intervention. The criterion standard for diagnosis of ovarian cancer was evaluation with exploratory laparotomy.
Main Outcome Measure:
Average years of life expectancy gained by women in the screened group.
Results:
Screening for ovarian cancer with a combination of CA 125 and transvaginal sonography increases the average life expectancy in the population by less than 1 day.
Conclusions:
Given the limited effect on overall life expectancy, it is unlikely that mass screening for ovarian cancer with CA 125 and transvaginal sonography would be an effective health policy.
