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Related Experiment Videos

Corticosteroid receptors and aging

D Armanini1, M Scali, G Vittadello

  • 1Istituto Semeiotica Medica, University of Padua, Italy.

The Journal of Steroid Biochemistry and Molecular Biology
|April 1, 1993
PubMed
Summary
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Aging is associated with decreased glucocorticoid and mineralocorticoid receptors in leukocytes, alongside elevated plasma cortisol. This suggests age-related receptor decline may drive cortisol level changes in healthy older adults.

Area of Science:

  • Endocrinology
  • Gerontology
  • Cell Biology

Background:

  • Aging affects hormonal regulation and cellular receptor function.
  • Glucocorticoid and mineralocorticoid receptors play key roles in cellular responses to stress and metabolism.

Purpose of the Study:

  • To investigate age-related changes in plasma aldosterone, plasma cortisol, and leukocyte glucocorticoid and mineralocorticoid receptors.
  • To explore correlations between these parameters and age in healthy individuals.

Main Methods:

  • Measured plasma aldosterone, plasma cortisol, and Type I/II receptors in mononuclear leukocytes.
  • Compared 54 healthy aged subjects (60-97 years) with 21 younger controls (21-50 years).
  • Correlated hormone levels and receptor counts with age.

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Main Results:

  • Aged subjects had significantly higher plasma cortisol than controls.
  • Plasma aldosterone levels did not differ between groups.
  • Both Type I and Type II receptors were significantly lower in aged subjects compared to controls.
  • Correlations indicated age-dependent decreases in receptors and increases in cortisol.

Conclusions:

  • The reduction in Type I and II receptors with age is not caused by elevated cortisol.
  • Increased plasma cortisol in aged individuals may result from age-dependent involution of these receptors.