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New bisphosphonates in osteoporosis

H Fleisch1

  • 1Department of Pathophysiology, University of Berne, Switzerland.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|January 1, 1993
PubMed
Summary

Bisphosphonates are potent bone resorption inhibitors with varying efficacy. These compounds are effective in treating bone diseases like osteoporosis and Paget

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Can bisphosphonates be given to patients with fractures?

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2001

Area of Science:

  • Pharmacology
  • Biochemistry
  • Bone Biology

Background:

  • Bisphosphonates are non-biodegradable compounds with a P-C-P bond.
  • They exhibit strong affinity for calcium phosphates.
  • Synthesis allows for diverse physical-chemical and biologic properties.

Purpose of the Study:

  • To investigate the efficacy of bisphosphonates in preventing and treating bone loss.
  • To understand the mechanism of action in inhibiting bone resorption.
  • To evaluate the therapeutic potential in osteoporosis and other bone diseases.

Main Methods:

  • Animal models of experimental osteoporosis (immobilization, ovariectomy, corticosteroids, low calcium diet).
  • Assessment of calcium absorption and retention.
  • Evaluation of bisphosphonate potency in inhibiting bone resorption in vitro and in vivo.

Main Results:

  • Bisphosphonates prevent various forms of experimental osteoporosis in rats.
  • They increase intestinal absorption and body retention of calcium.
  • Potency in inhibiting bone resorption varies significantly among different bisphosphonates.

Conclusions:

  • Bisphosphonates are effective in treating diseases with increased bone turnover, including osteoporosis.
  • They inhibit bone loss and can increase bone mass.
  • Low toxicity is attributed to rapid clearance, with long bone half-life.

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