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[Enzyme patterns in connective tissue proliferations (author's transl)]

W Fischer, G Werner, E Grund

    Zentralblatt Fur Allgemeine Pathologie U. Pathologische Anatomie
    |January 1, 1977
    PubMed
    Summary

    Investigating enzyme patterns in connective tissue tumors revealed increased activity of glucose-6-phosphate dehydrogenase and pyruvate kinase in recurrent cases. These findings suggest potential early biochemical markers for malignancy and disease progression.

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    Area of Science:

    • Biochemistry
    • Oncology
    • Pathology

    Context:

    • Benign and semimalignant connective tissue proliferations exhibit diverse cellular behaviors.
    • Understanding enzyme alterations in neoplasms is crucial for diagnosis and prognosis.
    • Comparative analysis with normal fascia provides a baseline for metabolic activity.

    Purpose:

    • To investigate alterations in the enzyme patterns of benign and semimalignant connective tissue proliferations.
    • To determine if enzyme activity changes in these conditions resemble those in malignant tumors.
    • To identify potential biochemical markers associated with tumor recurrence and deviation from benignity.

    Summary:

    • Enzyme activity patterns were analyzed in various connective tissue proliferations, including desmoids, fibromas, keloids, and Dupuytren's contractures.

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  • Recurring desmoids showed a twofold increase in most investigated enzymes.
  • Recurrent dermatofibrosarcoma protuberans and fibroma exhibited significantly high activities of glucose-6-phosphate dehydrogenase and pyruvate kinase.

    • Impact:

    • Elevated glucose-6-phosphate dehydrogenase and pyruvate kinase activities in recurrent tumors may indicate early signs of malignancy.
    • These enzyme alterations could serve as potential biochemical tools for evaluating and predicting disease course.
    • Further research is warranted to validate these findings for clinical application in tumor prognosis.