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Related Experiment Videos

Ferrous sulfate reduces cimetidine absorption

N R Campbell1, B B Hasinoff, J B Meddings

  • 1Department of Medicine, Faculty of Medicine, University of Calgary, Alberta, Canada.

Digestive Diseases and Sciences
|May 1, 1993
PubMed
Summary

Iron supplements significantly reduce cimetidine absorption. High doses of ferrous sulfate completely inhibited absorption, while lower doses caused a substantial reduction, highlighting potential drug interactions.

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Area of Science:

  • Pharmacology
  • Drug Interactions
  • Gastrointestinal Absorption

Background:

  • Many drugs binding to iron exhibit reduced absorption when coadministered with iron compounds.
  • Cimetidine's chemical structure suggests potential for strong iron ion binding.

Purpose of the Study:

  • To investigate the in vitro binding characteristics between iron and cimetidine.
  • To determine the in vivo effect of ferrous sulfate on cimetidine absorption using a rat jejunal model.

Main Methods:

  • In vitro experiments assessing iron-cimetidine binding.
  • In vivo isolated perfused rat jejunal model to evaluate drug absorption.
  • Administration of cimetidine (human equivalent 300 mg) with varying doses of ferrous sulfate (human equivalent 150 mg and 300 mg).

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Main Results:

  • In vitro studies confirmed iron binding to cimetidine.
  • In vivo, the higher ferrous sulfate dose (300 mg) completely inhibited cimetidine absorption (P < 0.01).
  • The lower ferrous sulfate dose (150 mg) reduced cimetidine absorption by 63% (P < 0.05).
  • In vitro, ferrous iron rapidly oxidized to ferric iron, which binds to cimetidine.

Conclusions:

  • Concurrent administration of ferrous sulfate significantly reduces cimetidine absorption.
  • Ferric iron binding to cimetidine is likely responsible for the observed decrease in absorption.
  • Caution is advised when prescribing iron supplements concurrently with cimetidine due to potential drug interactions.