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Starvation effect on rat kidney peroxisomal and microsomal fatty acid oxidation. A comparative study between liver
M Orellana1, O Fuentes, E Valdés
1Departamento de Bioquimica, Facultad de Medicina, Universidad de Chile, Santiago.
FEBS Letters
|May 3, 1993
Abstract:
Microsomal lauric acid 12-hydroxy lauric acid (omega)-hydroxylation and fatty acid peroxisomal beta-oxidation were studied in kidney tissue from starved rats. Starvation increased the microsomal omega-hydroxylation and peroxisomal beta-oxidation of fatty acids with a high correlation between both processes. Earlier, we reported similar results in liver. Our results support the hypothesis that the role of microsomal fatty acids omega-hydroxylation is the generation of substrate for peroxisomal beta-oxidation, with the final purpose of contributing to a catabolic or gluconeogenic pathway from fatty acids.