Related Experiment Video
Updated: Oct 17, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
The effects of acetylcholine on insulin-dependent and non-insulin-dependent diabetic rat tracheal segments
G Ozansoy1, C Karasu, V M Altan
1University of Ankara, Faculty of Pharmacy, Department of Pharmacology, Turkey.
Abstract:
1. In the present study, the contractile effects of acetylcholine (Ach) were investigated in isolated tracheal strips obtained from insulin-dependent (ID) and non-insulin-dependent (NID) diabetic rats. 2. The maximum responses to Ach were significantly decreased in 5-6 week ID diabetic rat tracheal segments compared with those from controls but, the sensitivity (pD2 values) of ID diabetic tracheas to Ach were not significantly altered relative to corresponding controls. 3. Tracheas isolated from 11-12 week NID diabetic rats exhibited reduced maximal contractile effect of Ach and also sensitivity (pD2 values) of NID diabetic tracheas to Ach were significantly decreased when compared to control rat tracheas. 4. Insulin treatment of both group of diabetic rats for 10 days corrected the changes observed in diabetic tracheas.
More Related Videos
08:22Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
Published on: March 20, 2017
04:41Glucose-Stimulated Insulin Secretion via Perfusion through the Mice Vasculature with an Intact Pancreas
Published on: July 25, 2025
Related Concept Videos
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Insulin: The Receptor and Signaling Pathways