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A possible mechanism for increased cerebrovascular permeability in diabetic rats: effects of insulin and
1Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Abstract:
1. Cerebrovascular permeability estimated as Evans blue extravasation significantly increased during insulin-induced hypoglycemia in both non-diabetic and diabetic rat groups. 2. Cerebrovascular permeability also increased significantly during 2-deoxy-glucose-induced intracellular glycopenia in both groups. 3. When a blood glucose level was fixed, cerebrovascular permeability showed no more significant change despite the hyperinsulinemic state in both groups. 4. Results suggest that hypoglycemia and/or intracellular glycopenia seems to be the major factor for increases in cerebrovascular permeability.
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