Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Fat-soluble vitamins: Intestinal absorption]

M Hanano1

  • 1College of Pharmacy, Nihon University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 1, 1993
PubMed
Summary

This study explores oral drug absorption, focusing on lipid-soluble vitamin E (dl-alpha-tocopherol). Bile acid micelles enhance tocopherol absorption more effectively than detergents, despite lower solubilization capacity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary Thrombocythemia in Japan: A Survey of 225 Patients.

Leukemia & lymphoma·2016
Same author

Pharmacokinetic/pharmacodynamic relationship of eptazocine, a narcotic-antagonist analgesic, in rats.

Biological & pharmaceutical bulletin·2001
Same author

Effect of the opioid antagonist naloxone on the regional metabolic rate for glucose in the conscious rat brain.

Biological & pharmaceutical bulletin·1999
Same author

Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.

The Journal of pharmacology and experimental therapeutics·1999
Same author

Change of beta-endorphin concentration in rat brain after administration of indomethacin or carrageenin.

Biological & pharmaceutical bulletin·1998
Same author

Pharmacokinetics of pentazocine and its occupancy of opioid receptors in rat brain.

Biological & pharmaceutical bulletin·1997

Area of Science:

  • Pharmacokinetics
  • Gastrointestinal Physiology
  • Nutrient Absorption

Context:

  • Oral drug administration involves complex absorption processes, including drug release, dissolution, and hepatic first-pass effect.
  • Lipid-soluble vitamins, like vitamin E (dl-alpha-tocopherol), exhibit unique absorption characteristics due to low water solubility.
  • Understanding these processes is crucial for optimizing drug delivery and nutritional strategies.

Purpose:

  • To investigate the solubilization and intestinal absorption of dl-alpha-tocopherol using bile acid micelles and a detergent.
  • To elucidate the influence of micelle characteristics and intestinal fluid dynamics on tocopherol absorption rate.
  • To compare the absorption efficiency of tocopherol solubilized in bile acid micelles versus polysorbate 80.

Summary:

  • General principles of oral drug absorption and bioavailability are discussed, highlighting factors like gastric emptying and intestinal transport.
  • The study examines dl-alpha-tocopherol's absorption, focusing on its solubilization in bile acid micelles and a detergent (polysorbate 80).
  • Results show faster absorption of tocopherol in bile acid micelles, with absorption rate highly dependent on intestinal volume flow, especially for smaller bile acid micelles.

Impact:

  • Provides insights into the enhanced intestinal absorption of lipid-soluble compounds facilitated by bile acid micelles.
  • Demonstrates the significant role of micelle size and intestinal fluid dynamics in modulating absorption rates.
  • Contributes to understanding vitamin E absorption mechanisms and potential strategies for improving oral bioavailability of lipophilic drugs.

Related Experiment Videos