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Related Experiment Videos

[Vitamin D]

C Miyaura1, T Suda

  • 1Department of Biochemistry, Showa University, School of Dentistry.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

The active form of vitamin D3, 1 alpha,25-Dihydroxyvitamin D3, regulates calcium levels and promotes cell differentiation. It acts by binding to vitamin D receptors (VDR) which influence gene expression in target cells.

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Area of Science:

  • Endocrinology and Molecular Biology
  • Cell Biology and Biochemistry

Context:

  • 1 alpha,25-Dihydroxyvitamin D3 (1 alpha,25(OH)2D3) is the active metabolite of vitamin D3.
  • It plays a crucial role in calcium homeostasis and bone metabolism.
  • Emerging research highlights its broader roles in cellular differentiation.

Purpose:

  • To review the mode of action of 1 alpha,25(OH)2D3.
  • To elucidate the diverse biological functions of 1 alpha,25(OH)2D3.
  • To explore its effects on various cell types and gene regulation.

Summary:

  • 1 alpha,25(OH)2D3 stimulates intestinal calcium absorption and bone resorption, increasing plasma calcium levels.
  • It induces differentiation in myeloid leukemia cells, lymphocytes, macrophages, and skin keratinocytes.

Related Experiment Videos

  • The mechanism involves the vitamin D receptor (VDR) binding to vitamin D-responsive elements (VDRE) in target genes.
  • In bone, it influences osteoblast protein synthesis and osteoclast differentiation.

    • Impact:

    • Provides a comprehensive understanding of 1 alpha,25(OH)2D3's molecular mechanisms.
    • Highlights the significance of vitamin D beyond calcium metabolism.
    • Offers insights into potential therapeutic applications in cell differentiation-related diseases.