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Comparative effect of nifedipine and S-adenosylmethionine, singly and in combination on experimental rat liver
E Barrio1, C Cutrín, M J Meniño
1Department of Medicine, Faculty of Medicine, University of Santiago de Compostela, Galicia, Spain.
Life Sciences
|January 1, 1993
Abstract:
An experimental rat liver cirrhosis, by means of carbon tetrachloride and ethanol during 8 weeks, was employed to assay the effect of Nifedipine (a calcium antagonist blocker), S-Adenosylmethionine (a precursor of glutathione); singly and in combination on rat liver cirrhosis. A slight decrease of cirrhosis (N.S.) was observed with the pharmacological therapy employed singly. The combination therapy (Nifedipine+S-Adenosylmethionine) significantly inhibited liver cirrhosis (p < 0.01).