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Dopaminergic function in two patients with catalepsy

P Cervantes, S Lal, F Smith

    Acta Psychiatrica Scandinavica
    |March 1, 1977
    PubMed
    Summary
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    Apomorphine, a dopamine agonist, did not alleviate catatonia in schizophrenic patients. This suggests schizophrenia-associated catalepsy may not stem from impaired dopaminergic function, unlike in animal models.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Catalepsy is a motor symptom in schizophrenia.
    • Dopaminergic pathways are implicated in animal models of catalepsy.
    • The role of dopamine in human schizophrenic catalepsy is not fully understood.

    Observation:

    • Apomorphine hydrochloride (2 mg subcutaneously) was administered to two schizophrenic patients exhibiting catalepsy.
    • In one patient, the response to apomorphine was compared with sodium amytal.
    • Growth hormone response to apomorphine (0.75 mg subcutaneously) was assessed in comparison to 25 control subjects.

    Findings:

    • Apomorphine administration showed no clinical effect on catalepsy in the schizophrenic patients.
    • Sodium amytal rapidly resolved catatonic symptoms, including catalepsy, in one patient.

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  • The peak growth hormone response to apomorphine in patients was comparable to that of control subjects.

    • Implications:

    • These findings suggest that catalepsy in schizophrenia may not be primarily driven by impaired dopaminergic function, unlike experimental models.
    • Further research with additional case studies and diverse dopamine receptor agonists is warranted.
    • This study challenges existing hypotheses regarding the neurochemical underpinnings of catatonic symptoms in schizophrenia.