Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postmenopausal oestrogen replacement therapy with subcutaneous oestradiol implants

S Suhonen1, S Sipinen, P Lähteenmäki

  • 1Department of Obstetrics and Gynaecology, City Maternity Hospital, Helsinki, Finland.

Maturitas
|March 1, 1993
PubMed
Summary

Subcutaneous oestradiol implants effectively relieved menopausal symptoms for up to 18 months. This hormone replacement therapy offers a safe and convenient alternative for women experiencing climacteric symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hanbury-Brown and Twiss exchange and non-equilibrium-induced correlations in disordered, four-terminal graphene-ribbon conductor.

Scientific reports·2018
Same author

Long-term clinical and economic outcomes in previously untreated paediatric patients with severe haemophilia A: A nationwide real-world study with 700 person-years.

Haemophilia : the official journal of the World Federation of Hemophilia·2018
Same author

Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents.

Leukemia·2017
Same author

Inhibitor development in previously untreated patients with severe haemophilia A: a nationwide multicentre study in Finland.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Complications associated with central venous access device in children with haemophilia: a nationwide multicentre study in Finland.

Haemophilia : the official journal of the World Federation of Hemophilia·2015
Same author

Cooper pair splitting by means of graphene quantum dots.

Physical review letters·2015

Area of Science:

  • Endocrinology
  • Gynecology
  • Pharmacology

Background:

  • Menopausal hormone therapy aims to alleviate climacteric symptoms.
  • Estrogen replacement therapy (ERT) is a common treatment for menopausal symptoms.
  • Controlled-release drug delivery systems offer potential advantages in hormone therapy.

Purpose of the Study:

  • To evaluate the efficacy and safety of subcutaneous oestradiol-releasing silastic implants for hormone replacement therapy.
  • To compare the effects of oestradiol valerate (E2V) and oestradiol benzoate (E2B) implants.
  • To assess the impact on hormonal levels, gynecological tissues, and climacteric symptom relief.

Main Methods:

  • Ten postmenopausal patients received either oestradiol valerate (E2V) or oestradiol benzoate (E2B) implants.

Related Experiment Videos

  • Serum hormone levels (estrone, estradiol, FSH, LH) were monitored.
  • Ultrasound and mammography assessed endometrial, uterine, and breast tissue changes.
  • Follow-up duration was 24 weeks, with implants removed upon symptom recurrence.

    • Main Results:

    • Sustained higher serum levels of estrone (E1) and estradiol (E2) were observed.
    • Suppressed levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were noted.
    • Positive estrogenic effects were evident in uterine and breast tissues.
    • Both E2V and E2B implants effectively relieved menopausal symptoms, with symptom return at 8-10 months post-insertion.

    Conclusions:

    • Nonbiodegradable, controlled-release oestrogen implants provide a safe, effective, and convenient option for hormone replacement therapy.
    • Subcutaneous oestradiol implants offer a well-accepted alternative to traditional hormone administration methods.
    • This delivery system demonstrates sustained efficacy in managing menopausal symptoms and hormonal balance.