Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bombesin acts in the brain to decrease gastric vagal efferent discharge in rats

E Yoshida-Yoneda1, J Y Wei, Y Taché

  • 1Center for Ulcer Research and Education, VA Wadsworth Medical Center, Los Angeles, CA 90073.

Peptides
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Study on mechanical properties of through-the-scope airway stents and complications caused by TTS airway stents in rabbits trachea].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

[Develop and assessment of a predictive model for the first-course efficacy of acute myeloid leukemia].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2025
Same author

[Effect and molecular mechanism of hesperadin-induced ferroptosis in chronic myeloid leukemia K562 cells].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2024
Same author

Deciphering the <i>in situ</i> phonon evolution of potassium sodium niobate under varying temperature and electric fields.

Physical chemistry chemical physics : PCCP·2024
Same author

[A comparison of R-CHOP and R-DA-EPOCH as a first-line regimen treatment of diffuse large B cell lymphoma with non-GCB subtypes: a retrospective study].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2022
Same author

[Clinical characteristics and prognostic factors of 40 cases of primary systemic anaplastic large cell lymphoma].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2020

Intracisternal and intravenous bombesin injections reduce gastric vagal efferent discharge (GVED) in rats. Central nervous system actions of bombesin inhibit basal GVED, as shown by antibody blockade studies.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Pharmacology

Background:

  • Bombesin's effects on the central nervous system (CNS) are complex.
  • Gastric vagal efferent discharge (GVED) plays a role in regulating gastric functions.

Purpose of the Study:

  • To investigate the CNS action of bombesin on basal GVED.
  • To determine if bombesin's effects on GVED are centrally mediated.

Main Methods:

  • Experiments were conducted in urethane-anesthetized rats.
  • Bombesin was administered intracisternally (IC) and intravenously (IV).
  • Gastric vagal efferent discharge (GVED) was measured.
  • A bombesin monoclonal antibody (2A11) was used for pretreatment.

Main Results:

Related Experiment Videos

  • IC bombesin dose-dependently decreased GVED.
  • IV bombesin also significantly reduced GVED.
  • Antibody pretreatment blocked the IV effect but not the IC effect of bombesin on GVED.

Conclusions:

  • Bombesin administration, both centrally and systemically, inhibits basal GVED.
  • The inhibitory effect of intracisternal bombesin on GVED is mediated by the central nervous system.