Diffuse small lymphoplasmacytic lymphoma of the GI tract associated with massive intestinal amyloidosis

We report the case of an 80 year old man who developed a small diffuse lymphoplasmacytic lymphoma that involved the entire gastrointestinal tract. The malignant lymphoma was associated with intestinal amyloidosis presumably produced by the neoplastic lymphocytes. The outstanding symptoms were asthenia, fever, marked weight loss, diarrhea and melena. The postmortem study disclosed, in addition, lymphomatous infiltration to the gallbladder, mesenteric lymph nodes and testis. The case represents an exceptionally widespread type of diffuse gastrointestinal lymphoma.