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Hypogammaglobulinemia and rheumatic disease
A H Lee1, A I Levinson, H R Schumacher
1Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia.
Seminars in Arthritis and Rheumatism
|February 1, 1993
Summary
Primary hypogammaglobulinemia, including common variable immunodeficiency, increases infection and rheumatologic risks. Some medications used for autoimmune diseases can also cause hypogammaglobulinemia.
Area of Science:
- Immunology
- Rheumatology
- Infectious Diseases
Background:
- Primary hypogammaglobulinemia encompasses disorders like X-linked agammaglobulinemia, common variable immunodeficiency, and IgA deficiency.
- These conditions primarily manifest as recurrent infections, particularly from encapsulated bacteria.
- A significant association exists between hypogammaglobulinemia and various rheumatologic and autoimmune disorders.