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Cigarette smoking and methadone dose levels

M J Stark1, B K Campbell

  • 1Oregon Health Division, Portland 97232.

The American Journal of Drug and Alcohol Abuse
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Higher methadone doses did not increase cigarette smoking in patients. This study found no correlation between methadone dosage and smoking rates, suggesting dosage decisions can be based on other factors.

Area of Science:

  • Addiction Medicine
  • Clinical Pharmacology
  • Behavioral Science

Background:

  • Acute methadone administration can increase cigarette smoking.
  • Higher methadone doses may be linked to increased smoking due to potential benefits in illicit drug use and treatment retention.

Purpose of the Study:

  • To test the hypothesis that higher maintenance doses of methadone are associated with increased cigarette smoking.
  • To investigate the relationship between methadone maintenance dose levels and smoking rates.

Main Methods:

  • Two experiments were conducted to assess smoking.
  • Smoking was measured using self-report and expired carbon monoxide (CO).
  • Data were correlated with subjects' methadone dose levels.

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Main Results:

  • 85% of subjects reported smoking cigarettes.
  • Self-reported smoking significantly correlated with CO levels (r = -.52).
  • No significant correlation was found between methadone maintenance doses and smoking levels.

Conclusions:

  • Methadone maintenance dose levels are not correlated with cigarette smoking rates.
  • The acute effects of methadone on smoking appear to be nullified by habituation to the dose.
  • Methadone dosage decisions can be based on factors other than smoking rates.