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Related Experiment Videos

Decrease in calcitonin-containing cells in truncus arteriosus

C Gamallo1, M García, J Palacios

  • 1Department of Pathology, La Paz Hospital, Madrid, Spain.

American Journal of Medical Genetics
|April 15, 1993
PubMed
Summary
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Neural crest abnormalities are implicated in truncus arteriosus (TA), a heart defect. This study found fewer neural crest-derived cells in the thyroids of infants with isolated TA, supporting the neural crest disturbance hypothesis.

Area of Science:

  • Developmental Biology
  • Cardiology
  • Endocrinology

Background:

  • Truncus arteriosus (TA) is a conotruncal cardiac defect.
  • Experimental studies suggest cranial neural crest abnormalities cause TA.
  • Human data for isolated TA and neural crest involvement are lacking.

Purpose of the Study:

  • To investigate the role of cranial neural crest in isolated TA in humans.
  • To assess calcitonin-immunoreactive cells (C-cells) as a marker for neural crest-derived cells in the thyroid.
  • To determine if the proportion of thyroid C-cells is altered in patients with isolated TA.

Main Methods:

  • Immunohistochemical analysis of thyroid sections from 15 patients with isolated TA and 11 age-matched controls.
  • Quantification of calcitonin-containing cells (C-cells) and their volume density.

Related Experiment Videos

  • Autopsy-based study to evaluate C-cell number and distribution.

    • Main Results:

    • Significantly lower volume density of C-cells in TA patients (0.888%) compared to controls (3.475%).
    • Significantly fewer C-cells per follicle in TA patients (0.991) than in controls (2.367).
    • These findings indicate a reduction in neural crest-derived cells in the thyroid of infants with isolated TA.

    Conclusions:

    • The reduced proportion of neural crest-derived C-cells in the thyroid supports a neural crest origin for isolated TA.
    • This suggests more widespread abnormalities than clinically apparent in isolated TA.
    • Neural crest cell disturbance is a likely pathogenetic factor in truncus arteriosus.