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Yersinia associated arthritis in SHR rats: effect of the microbial status of the host
C Gripenberg-Lerche1, P Toivanen
1Department of Medical Microbiology, Turku University, Finland.
Annals of the Rheumatic Diseases
|March 1, 1993
Abstract:
Following the intravenous injection of live Yersinia enterocolitica O:8, 50-69% of SHR rats developed arthritis; these rats were antibody free against all rat pathogens tested. In contrast, only 20-25% of SHR rats which had serum antibodies against Bacillus piliformis, Kilham rat virus, and Toolan H-1 virus developed arthritis. The results indicate that the microbial load of the host has a profound effect on the susceptibility to experimental arthritis.