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Change of paraprotein from IgG lambda to lambda chain in myeloma
M Sawamura1, K Murayama, S Tokizawa
1Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
Annals of Hematology
|April 1, 1993
Summary
This study details a rare IgG lambda myeloma case that progressed to plasma cell leukemia. The paraprotein shifted to lambda chain, causing fatal kidney failure, with J-chain found in leukemia cells.
Area of Science:
- Hematology
- Nephrology
- Oncology
Background:
- Multiple myeloma is a plasma cell malignancy.
- IgG lambda myeloma is a subtype characterized by the production of IgG lambda paraproteins.
- Plasma cell leukemia is an aggressive form of multiple myeloma.