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Mitochondrial abnormalities in progressive external ophthalmoplegia

B N Hyman, B M Patten, R F Dodson

American Journal of Ophthalmology

|March 1, 1977

Summary

Chronic progressive external ophthalmoplegia is linked to abnormal mitochondria in muscle fibers. These mitochondrial defects may cause widespread metabolic issues, suggesting a diffuse mitochondrial disease.

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Area of Science:

Neurology
Mitochondrial Biology
Muscle Physiology

Background:

Chronic progressive external ophthalmoplegia (CPEO) is a rare neuromuscular disorder.
Ragged-red fibers are a histological hallmark observed in muscle biopsies of patients with mitochondrial myopathies.