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Histamine in human tears

M B Abelson, N A Soter, M A Simon

    American Journal of Ophthalmology
    |March 1, 1977
    PubMed
    Summary
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    Histamine was detected in tears from both healthy individuals and those with vernal conjunctivitis. This finding suggests histamine plays a role in normal eye physiology and allergic eye disease.

    Area of Science:

    • Ophthalmology
    • Immunology
    • Biochemistry

    Background:

    • Histamine is a key mediator in allergic reactions.
    • The role of histamine in external eye tissues is not fully understood.

    Purpose of the Study:

    • To quantify histamine levels in human tears.
    • To investigate the presence of histamine in normal and vernal conjunctivitis tears.

    Main Methods:

    • Tear samples were collected from 13 normal volunteers and 9 patients with vernal conjunctivitis.
    • Histamine concentrations in tear samples were determined using biochemical assays.

    Main Results:

    • Histamine was present in tears of all subjects.
    • Normal subjects had mean histamine levels of 10.3 ng/ml (range: 2.2-36 ng/ml).

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  • Vernal conjunctivitis patients exhibited higher mean histamine levels of 33.2 ng/ml (range: 0-125 ng/ml).

    • Conclusions:

    • The presence of histamine in tears confirms its involvement in ocular physiology.
    • Elevated histamine in vernal conjunctivitis suggests its role in this allergic eye condition.