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Equine Cushing's disease

S Love1

  • 1Department of Veterinary Medicine, University of Glasgow Veterinary School, Bearsden.

The British Veterinary Journal
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Equine Cushing's disease, linked to pituitary gland tumors, involves excessive hormone secretion. Dopamine agonists can help manage symptoms, and insulin activity may predict prognosis in affected horses.

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Area of Science:

  • Veterinary Endocrinology
  • Equine Medicine
  • Neuroendocrinology

Background:

  • Equine Cushing's disease is associated with pituitary pars intermedia adenomas.
  • This condition results from excessive secretion of adrenocorticotropin (ACTH) and other proopiomelanocortin (POMC) peptides.
  • Dopaminergic control of the pituitary pars intermedia suggests therapeutic targets.

Purpose of the Study:

  • To explore endocrinological abnormalities in equine Cushing's disease.
  • To investigate the role of carbohydrate metabolism and insulin activity.
  • To assess the potential of insulin activity as a prognostic index.

Main Methods:

  • Review of clinical and endocrinological data in horses with Cushing's disease.
  • Analysis of hormone secretion patterns, including ACTH and POMC peptides.

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  • Evaluation of carbohydrate metabolism and peripheral insulin resistance.

    • Main Results:

    • Hyperadrenocorticism, peripheral insulin resistance, and excessive POMC peptide secretion are common.
    • Dopamine agonists like pergolide can alleviate clinical signs.
    • Preliminary data suggest insulin activity correlates with disease severity.

    Conclusions:

    • Equine Cushing's disease involves complex hormonal dysregulation.
    • Insulin activity quantification may serve as a prognostic indicator.
    • Insulin therapy might be beneficial for secondary diabetes mellitus in these horses.