Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Catecholamine metabolism during heroin use

J J Schildkraut, R E Meyer, P J Orsulak

    The American Journal of Psychiatry
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    PD/PDT for gynecological disease: A clinical review.

    Photodiagnosis and photodynamic therapy·2014
    Same author

    Peroneal intraneural ganglion.

    Orthopedics·2014
    Same author

    Breakage of the metal tray in total knee replacement.

    Orthopedics·2014
    Same author

    Endometrial carcinoma: the current role of adjuvant radiation.

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2009
    Same author

    Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study.

    Journal of affective disorders·2008
    Same author

    Robotic assisted spinal surgery--from concept to clinical practice.

    Computer aided surgery : official journal of the International Society for Computer Aided Surgery·2007
    Same journal

    2026 Annual Meeting: President-Elect Address.

    The American journal of psychiatry·2026
    Same journal

    2026 Annual Meeting: CEO and Medical Director's Address.

    The American journal of psychiatry·2026
    Same journal

    Reports to the Membership.

    The American journal of psychiatry·2026
    Same journal

    Convergent Metabolic Dysregulations But Divergent Contributing Pathways Across Severe Mental Disorders: The Power of Combining Genetics and Metabolomics.

    The American journal of psychiatry·2026
    Same journal

    2026 Annual Meeting: Presidential Address.

    The American journal of psychiatry·2026
    Same journal

    Represcribing Previously Used Antipsychotics: Response to So.

    The American journal of psychiatry·2026
    See all related articles

    Heroin use alters urinary catecholamines, increasing normetanephrine and decreasing metanephrine. Some users showed increased 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion, potentially due to conditioned responses before drug administration.

    Area of Science:

    • Neuroendocrinology
    • Pharmacology
    • Addiction Research

    Background:

    • Opioid use, including heroin, significantly impacts physiological systems.
    • Understanding the metabolic changes associated with heroin use is crucial for addiction research and treatment.
    • Catecholamines and their metabolites are key indicators of stress and physiological response.

    Purpose of the Study:

    • To investigate changes in urinary catecholamine and metabolite excretion during a 10-day period of heroin use.
    • To identify specific patterns of metabolite excretion in response to heroin administration.
    • To explore potential anticipatory or conditioned responses related to MHPG excretion.

    Main Methods:

    • Collection and analysis of urinary samples from 9 subjects over a 10-day heroin use period.

    Related Experiment Videos

  • Measurement of catecholamines and their metabolites, including normetanephrine, metanephrine, and 3-methoxy-4-hydroxyphenyl glycol (MHPG).
  • Comparison of excretion levels during heroin use against baseline values.

    • Main Results:

    • Urinary catecholamine and metabolite excretion increased on the first day of heroin use.
    • All subjects showed a significant increase in normetanephrine and a decrease in metanephrine.
    • Only 4 subjects exhibited increased 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion, with some showing increases prior to heroin administration.

    Conclusions:

    • Heroin use induces distinct changes in catecholamine metabolite excretion patterns.
    • The observed increase in MHPG, potentially preceding heroin use, suggests a conditioned or anticipatory physiological response.
    • These findings contribute to understanding the neurobiological adaptations associated with chronic heroin use and addiction.