Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The tidal volume response to incremental exercise in COPD

C A Vaz Fragoso1, T Clark, A Kotch

  • 1Section of Pulmonary and Critical Care Medicine, Danbury Hospital, Conn 06810.

Chest
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Māori Models of Adult Inpatient Mental Health Services: An Integrative Literature Review.

International journal of mental health nursing·2026
Same author

Genetic variation of macronutrient tolerance in Drosophila melanogaster.

Nature communications·2022
Same author

Advanced quantitative evaluation of PET systems using the ACR phantom and NiftyPET software.

Medical physics·2022
Same author

National estimates from the Youth '19 Rangatahi smart survey: A survey calibration approach.

PloS one·2021
Same author

Training injury incidence in an amateur women's rugby union team in New Zealand over two consecutive seasons.

Journal of science and medicine in sport·2020
Same author

Using carbon nanodots as inexpensive and environmentally friendly sensitizers in mesoscopic solar cells.

Nanoscale horizons·2020

In severe COPD patients, a larger tidal volume (VT) response during exercise is linked to greater airway obstruction and lung hyperinflation. This breathing pattern may help reduce auto-PEEP and improve oxygen delivery during exertion.

Area of Science:

  • Pulmonary Medicine
  • Exercise Physiology
  • Respiratory System

Background:

  • Severe COPD patients often face exercise limitations due to ventilatory constraints.
  • Breathing patterns during exercise vary significantly in COPD patients, but influencing factors are not fully understood.

Purpose of the Study:

  • To investigate the factors influencing tidal volume (VT) response during maximal incremental exercise in patients with severe COPD.

Main Methods:

  • Nine patients with severe COPD underwent maximal incremental exercise testing.
  • Pulmonary function tests, expired gas analysis, and continuous pulse oximetry were performed.
  • Regression analysis was used to correlate tidal volume with various physiological parameters.

Main Results:

Related Experiment Videos

  • Peak tidal volume (PKVT) was inversely correlated with FEV1 and respiratory rate, and positively correlated with FRC and PKO2sat.
  • More severe obstruction and hyperinflation were associated with a larger VT response.
  • An earlier anaerobic threshold (AT) and higher PKO2sat showed a trend towards association with larger PKVT.

Conclusions:

  • In severe COPD, increased VT during exercise may be a compensatory mechanism to mitigate auto-PEEP and improve expiratory time.
  • This breathing strategy might also help minimize the impact of dead space and auto-PEEP on oxygen delivery, particularly indicated by an earlier AT.