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d-alpha-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular
N K Ozer1, P Palozza, D Boscoboinik
1Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
FEBS Letters
|May 17, 1993
Abstract:
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.