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Gonadotropin responsiveness to ultralow-dose leuprolide acetate administration in baboons
R T Scott1, K D Carey, M Leland
1Department of Obstetrics and Gynecology, Wilford Hall, USAF Medical Center, Lackland AFB, Texas 78236.
Objective:
To evaluate the gonadotropin response to ultralow doses of a GnRH agonist, leuprolide acetate (LA).
Design:
Prospective and cross-controlled.
Setting:
Primate research center.
Subjects:
Four reproductive age cycling baboons (Papio cyanocephalus).
Interventions:
Three different doses of LA were given intravenously to each animal followed by serial sampling.
Main Outcome Measures:
Response patterns of circulating serum gonadotropin levels.
Results:
All four animals responded to each of the three doses of LA in a dose-dependent fashion. Levels of LH and FSH peaked at 49.5 +/- 2.6 mIU/mL and 72.5 +/- 3.4 mIU/mL, respectively, for the highest dose studied (0.17 microgram/kg). Levels of LH peaked earlier but were lower than the FSH peak levels.
Conclusions:
Supraphysiological levels of gonadotropins are attained after the administration of ultralow doses of LA. The level of the response is dose-dependent and is in the range that is required to attain controlled ovarian hyperstimulation.