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Local and systemic immunity against Streptococcus pneumoniae: humoral responses against a non-capsulated
V E García1, M M Gherardi, M F Iglesias
1Department of Microbiology, Parasitology and Immunology, School of Medicine, University of Buenos Aires, Argentina.
FEMS Microbiology Letters
|April 1, 1993
Abstract:
Temperature-sensitive mutants of Streptococcus pneumoniae were isolated after chemical mutagenesis. Intranasal immunization with temperature-sensitive mutant J/3 induced higher levels of circulating antibody than those obtained after immunization with the heat-killed parental wild type. Moreover, local immunization with mutant J/3 induced high levels of anti-S. pneumoniae IgG and IgA in the lower respiratory tract, whereas only moderate IgG (and no IgA) antibodies were detected in lung lavage fluids from mice immunized intranasally with the heat-killed strain.