Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrastructural study of vitiligo

E Galadari1, A H Mehregan, K Hashimoto

  • 1Department of Dermatology, United Arab Emirates University, Dubai.

International Journal of Dermatology
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cutaneous malakoplakia: a report of two cases with the use of anti-BCG for the detection for micro-organisms.

Journal of the American Academy of Dermatology·2000
Same author

Histologic diagnosis of cutaneous leishmaniasis.

Clinics in dermatology·1999
Same author

Staining of eccrine and apocrine neoplasms and metastatic adenocarcinoma with IKH-4, a monoclonal antibody specific for the eccrine gland.

Journal of cutaneous pathology·1998
Same author

Detection of Borrelia burgdorferi DNA (B garinii or B afzelii) in morphea and lichen sclerosus et atrophicus tissues of German and Japanese but not of US patients.

Archives of dermatology·1997
Same author

Nodular myxoid change in melanocytic nevi. A report of two cases.

The American Journal of dermatopathology·1996
Same author

Amelanotic Spitzoid melanoma in the burn scar of a child.

Pediatric dermatology·1996
Same journal

Updated Vitiligo Trends in the Burden of Psychiatric and Autoimmune Diseases.

International journal of dermatology·2026
Same journal

SENTINOLD and the Challenge of Meaningful Risk Prediction in Melanoma.

International journal of dermatology·2026
Same journal

The "Stamp-n-Tack" Technique: An Ink-Guided Precision Method for Anchoring Tissue After Releasing Facial Retaining Ligaments in Large Facial Flap Reconstruction.

International journal of dermatology·2026
Same journal

Counterfactual Dermatology With Generative Models.

International journal of dermatology·2026
Same journal

Correlation of Clinical and Histopathological Features With Anti-Desmoglein Antibody Profile in Pemphigus Patients.

International journal of dermatology·2026
Same journal

Paracetamol-Induced Generalized Bullous Fixed Drug Eruption With Positive Anti-BP230 Antibody and Confirmed With Oral Provocation Test in a Child: A Case Report From the Philippines.

International journal of dermatology·2026
See all related articles

Early vitiligo (pigment loss) shows abnormal melanocytes, while long-standing lesions lack them. Early treatment is recommended for potential repigmentation from hair follicle melanocytes.

Area of Science:

  • Dermatology
  • Cell Biology
  • Histopathology

Background:

  • Vitiligo is a common skin condition causing patchy depigmentation.
  • A comparative ultrastructural study examined early (2-6 months) and long-standing (1-5 years) vitiligo lesions.

Purpose of the Study:

  • To compare the ultrastructural characteristics of early and long-standing vitiligo lesions.
  • To investigate the presence and state of melanocytes in different stages of vitiligo.

Main Methods:

  • Skin biopsy specimens from ten vitiligo patients were collected.
  • Specimens were processed, stained, and examined using electron microscopy.

Main Results:

  • No melanocytes were detected in long-standing vitiligo lesions.

Related Experiment Videos

  • Early vitiligo lesions exhibited junctional melanocytes with cellular abnormalities.
  • Epidermal keratinocytes remained normal; minor degenerative changes were noted at the periphery of early lesions.

    • Conclusions:

    • Repigmentation in long-standing vitiligo may rely on the melanocytic reservoir in hair follicles.
    • Early vitiligo lesions may repigment through reactivation of existing melanocytes.
    • Treatment of vitiligo should target early-stage lesions for better outcomes.