Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular pathology in leprosy. An electron microscopic study

A Date, A Thomas, R Mathai

    The American Journal of Tropical Medicine and Hygiene
    |March 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Performance of TB Antigen-Based Skin Tests Amongst Healthcare Workers-Sevagram, India, 2023-2024.

    Open forum infectious diseases·2026
    Same author

    HIGHLIGHTS OF ADVANCES IN MEDICAL RETINA FROM THE VIRTUAL WORLD OPHTHALMOLOGY CONGRESS 2020.

    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti·2021
    Same author

    Improving sputum collection processes to increase tuberculosis case finding among HIV-positive persons in Botswana.

    Public health action·2020
    Same author

    Assessment of routine screening of pediatric contacts of adults with tuberculosis disease in Tanzania.

    Public health action·2020
    Same author

    Modular protein switches derived from antibody mimetic proteins.

    Protein engineering, design & selection : PEDS·2015
    Same author

    Expanding human immunodeficiency virus testing and counseling to reach tuberculosis clients' partners and families.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2015
    Same journal

    Long-Term Mortality among Hospitalized Adults with Sepsis in Uganda: A Prospective Cohort Study.

    The American journal of tropical medicine and hygiene·2026
    Same journal

    Arbovirus Circulation among Patients with Acute Encephalitis: West Nile Virus Infection among Humans in Bangladesh, 2022.

    The American journal of tropical medicine and hygiene·2026
    Same journal

    Vitamin D Deficiency and Severe Dengue Fever: A Systematic Review and Meta-Analysis.

    The American journal of tropical medicine and hygiene·2026
    Same journal

    The Weather-Child Morbidity Link and the Modifying Effect of Maternal Education and Sanitation: Evidence from Sub-Saharan Africa.

    The American journal of tropical medicine and hygiene·2026
    Same journal

    Use of a Gamification Platform to Teach Tropical Medicine: A Pilot Study.

    The American journal of tropical medicine and hygiene·2026
    Same journal

    The Proposed United States Office of Management and Budget Rule for Managing Biomedical Research Grants and Cooperative Agreements Needs to Change.

    The American journal of tropical medicine and hygiene·2026
    See all related articles

    Kidney disease, specifically proliferative glomerulonephritis, affects many leprosy patients with kidney symptoms. This study examined renal biopsies to understand the kidney lesions associated with leprosy.

    Area of Science:

    • Nephrology
    • Immunology
    • Infectious Diseases

    Background:

    • Leprosy can manifest with renal complications, including edema, proteinuria, and hematuria.
    • The specific renal pathologies and their associations in leprosy patients require further elucidation.

    Purpose of the Study:

    • To investigate the spectrum of kidney lesions in leprosy patients presenting with renal abnormalities.
    • To correlate specific glomerulonephritis patterns with clinical findings and potential contributing factors.

    Main Methods:

    • Electron microscopic examination of renal biopsies from 19 leprosy patients with renal symptoms.
    • Analysis of clinical data, including serum complement levels, erythema nodosum leprosum, recent streptococcal infection, and microfilariae detection.

    Related Experiment Videos

    Main Results:

    • Proliferative glomerulonephritis was observed in 12 of 19 patients, with varied patterns (diffuse, focal, mesangial).
    • Amyloidosis was found in 2 patients; 5 showed no significant renal lesions.
    • Subendothelial and/or subepithelial deposits were present in five biopsies.
    • Associated factors in glomerulonephritis patients included reduced serum complement (3), erythema nodosum leprosum (5), recent streptococcal infection (5), and microfilariae (2).

    Conclusions:

    • Proliferative glomerulonephritis is a significant renal manifestation in leprosy patients with kidney dysfunction.
    • The pathogenesis may involve immune complex deposition, potentially triggered by leprosy itself or concurrent infections/conditions.
    • Further research is warranted to clarify the precise mechanisms and clinical implications.