Sudden death revealing Chiari type 1 malformation in two children
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Updated: Nov 6, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
1Department of Pediatric Intensive Care, Centre Hospitalier Regional Universitaire, Lille, France.
Insights
Sudden cardiorespiratory arrest in children may indicate undiagnosed Arnold-Chiari type 1 malformation. Early neurosurgery is crucial for Arnold-Chiari type 1 malformation to prevent sudden death.
Area of Science:
- Neurology
- Pediatrics
- Cardiology
Background:
- Arnold-Chiari type 1 malformation is a congenital condition affecting brain structure.
- Sudden unexplained cardiorespiratory arrest is a critical emergency in pediatric care.
Observation:
- Two pediatric cases of sudden, unprovoked cardiorespiratory arrest were identified.
- Both children had previously undiagnosed Arnold-Chiari type 1 malformation.
Findings:
- This study highlights a potential link between Arnold-Chiari type 1 malformation and sudden cardiorespiratory arrest in children.
- Undiagnosed Arnold-Chiari type 1 malformation may present as unexplained cardiorespiratory arrest.
Implications:
- Arnold-Chiari type 1 malformation should be considered in the differential diagnosis of pediatric cardiorespiratory arrest.
- The findings underscore the importance of early neurosurgical intervention for Arnold-Chiari type 1 malformation to mitigate risks.
- This research emphasizes the need for increased awareness among clinicians regarding the neurological complications of Arnold-Chiari malformations.
Abstract:
We report the first two fatal cases of sudden unprovoked cardiorespiratory arrest in children with previously undiagnosed Arnold-Chiari type 1 malformation. This diagnosis should be considered in children with unexplained cardiorespiratory arrest. The risk of sudden death in Arnold-Chiari type 1 malformation reinforces the indication for early neurosurgical procedure.