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Updated: Jul 20, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
[Embolism due to cholesterol crystals]
J Pérez Villoria1, J M Ayuela Azcárate, M J López Pueyo
1Sección de Cardiología, Hospital General Yagüe, Burgos.
Insights
Cholesterol crystal embolization, a serious condition, was confirmed via skin biopsy and retinal examination. Despite potential for fatal outcomes, this patient experienced a favorable clinical course.
Area of Science:
- Ophthalmology
- Cardiology
- Dermatology
Background:
- Cholesterol crystal embolization is a rare but serious complication often linked to cardiovascular procedures.
- Risk factors include anticoagulation, coronary angiography, and stent implantation.
Observation:
- A patient presented with clinical signs suggestive of cholesterol crystal embolization.
- Histological examination of a skin biopsy revealed characteristic yellowish, refringent microemboli.
- Ophthalmoscopic examination identified similar microemboli within retinal arterioles.
Findings:
- The diagnosis of cholesterol crystal embolization was confirmed through histological and clinical evidence.
- The patient had undergone coronary angiography with stent implantation and was on anticoagulation therapy.
Implications:
- This case highlights the importance of considering cholesterol crystal embolization in patients with relevant procedural history.
- Early diagnosis and recognition are crucial, even though the condition can be severe.
- Favorable outcomes are possible despite the typically grave prognosis of cholesterol crystal embolization.
Abstract:
We present a case of cholesterol crystal embolization confirmed histologically by skin biopsy and by the presence of a yellowish microemboli with a refringent look lodged inside a retinal arterioles. The presence of a typical clinic case history, together concurrent risk factor (coronarography, implantation of stent and anticoagulation) supported the diagnostic suspicion. Although it is a serious illness, often with a fatal evolution, the patient has followed a favourable clinic course.
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