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Space flight and the immune system

A Cogoli1

  • 1Space Biology Group Institute of Biotechnology, ETH Hönggerberg, Zürich, Switzerland.

Vaccine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Spaceflight suppresses immune cell function in astronauts, impacting lymphocyte response. Understanding these immunological changes is crucial for long-duration space missions.

Area of Science:

  • Immunology
  • Space Medicine
  • Space Physiology

Background:

  • Immune system depression, specifically reduced lymphocyte response to mitogens, has been observed in cosmonauts since the 1970s.
  • Approximately 50% of space crew members experience impaired lymphocyte function.
  • Ground-based studies link physical and psychological stress to immune depression in astronauts.

Purpose of the Study:

  • To investigate the immunological changes in astronauts due to spaceflight.
  • To understand the impact of stress and weightlessness on immune function for future long-duration missions.

Main Methods:

  • Analysis of lymphocyte response to mitogens in cosmonauts post-flight.
  • In vitro studies on the effect of weightlessness on lymphocyte activation.
Keywords:
NASA Discipline Number 00-00NASA Discipline Regulatory PhysiologyNASA Program FlightNon-NASA Center

Related Experiment Videos

  • Ground-based simulations involving physical and psychological stress.

    • Main Results:

    • Spaceflight demonstrably depresses lymphocyte response to mitogens in astronauts.
    • Weightlessness exhibits a significant inhibitory effect on lymphocyte activation in vitro.
    • Stress is identified as a key contributor to immune depression in space crews.

    Conclusions:

    • Immunological changes, while not currently health-harming, require thorough investigation.
    • Understanding these immune alterations is vital for ensuring astronaut health during extended space missions, including lunar and Martian exploration.