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Development of a hybrid bioartificial liver
1Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
Annals of Surgery
|May 1, 1993
Summary
This study presents a novel hybrid liver support system using porcine hepatocytes. The system demonstrated significant improvements in liver failure markers in animal models and was well-tolerated in a human patient.
Area of Science:
- Hepatology
- Biomedical Engineering
- Regenerative Medicine
Background:
- Acute severe liver failure necessitates effective support systems.
- Existing liver support technologies, such as plasma exchange and charcoal columns, have limited clinical application.
- There is a critical need for liver support as a bridge to transplantation and for managing potentially reversible liver dysfunction.