Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sympathetic dysfunction in heart failure

K Shimizu1, B P McGrath

  • 1Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

Bailliere'S Clinical Endocrinology and Metabolism
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The morning blood pressure surge is related to serum cholesterol.

Journal of human hypertension·2012
Same author

Advanced chronic kidney disease, cardiovascular events and the effect of diabetes: data from the Atherosclerosis and Folic Acid Supplementation Trial.

Internal medicine journal·2010
Same author

Exchanges across land-water-scape boundaries in urban systems: strategies for reducing nitrate pollution.

Annals of the New York Academy of Sciences·2008
Same author

Is venous reflux a common disease in post-thrombotic patients with unilateral deep vein thrombosis episode?

Phlebology·2008
Same author

Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease.

The Journal of clinical endocrinology and metabolism·2005
Same author

Vascular dysfunction and metabolic parameters in polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism·2005
Same journal

Phytoestrogen content in foods.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Soyfoods, isoflavones and risk of colonic cancer: a review of the in vitro and in vivo data.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Experimental studies on lignans and cancer.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Reproductive actions of phytoestrogens.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Phytoestrogens and inhibition of angiogenesis.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Phytoestrogens and diseases of the prostate gland.

Bailliere's clinical endocrinology and metabolism·1999
See all related articles

Sympathetic nervous system overactivity is key in heart failure, affecting blood flow and fluid balance. Treatments and heart transplants impact this activity, influencing patient outcomes.

Area of Science:

  • Cardiology
  • Nephrology
  • Neuroscience

Background:

  • Congestive heart failure (CHF) is a complex syndrome where increased peripheral vascular tone significantly contributes to its pathophysiology.
  • Elevated sympathetic nervous system activity, particularly early in CHF development, increases cardiac afterload.
  • This sympathetic overactivity is unevenly distributed, with heightened activity in the heart and kidneys but not the lungs.

Purpose of the Study:

  • To explore the role of sympathetic nervous system activity in congestive heart failure (CHF) pathophysiology.
  • To investigate the regional distribution and functional impact of sympathetic alterations in CHF.
  • To examine the interactions between the sympathetic nervous system and other humoral systems in CHF.

Main Methods:

Related Experiment Videos

  • Review of existing literature on sympathetic nervous system function in CHF.
  • Analysis of regional sympathetic activity patterns in CHF patients.
  • Examination of the effects of CHF medications and cardiac transplantation on sympathetic activity.

    • Main Results:

    • Increased sympathetic activity in CHF affects hemodynamics, sodium/water retention, and blood flow distribution, especially during exercise.
    • Disordered cardiovascular reflexes contribute to aberrant sympathetic function in CHF.
    • Sympathetic nervous system interacts with hormonal systems like renin-angiotensin, AVP, ANP, endothelin, and renal DA.
    • Therapeutic interventions like ACE inhibitors can suppress sympathetic activity, while diuretics may increase it.
    • Cardiac transplantation generally normalizes sympathetic function, though cardiac reinnervation is gradual; cyclosporine may increase sympathetic activity.

    Conclusions:

    • Sympathetic nervous system dysregulation is a critical component of CHF, influencing its progression and clinical manifestations.
    • Understanding these sympathetic alterations is vital for developing effective CHF treatments.
    • Therapeutic strategies targeting the sympathetic nervous system, alongside other humoral systems, are crucial for managing CHF and post-transplant complications.