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Morphometric computerized analysis as a method to assess skin atrophy caused by corticosteroids
C Pelfini1, M Vignini, A Calligaro
1Department of Dermatology, Ospedale S. Anna, USSL 11, Como, Italy.
Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1993
Summary
Computerized morphometric analysis accurately quantifies skin atrophy, correlating well with subjective assessments. This method objectively differentiates topical corticosteroid potencies, aiding in clinical evaluations.
Area of Science:
- Dermatology
- Image Analysis
Background:
- Skin atrophy is a common side effect of topical corticosteroid use.
- Accurate quantification of skin atrophy is essential for evaluating drug efficacy and safety.
Purpose of the Study:
- To evaluate the efficacy of morphometric computerized analysis in quantifying skin atrophy.
- To compare computerized analysis with subjective assessments of skin atrophy.
- To determine if computerized analysis can differentiate between corticosteroid potencies.
Main Methods:
- Skin atrophy was induced in volunteers using the Duhring chamber assay with topical corticosteroids.
- Replicas of atrophic skin areas were captured and stored digitally.
- An interactive computerized image analysis system (Kontron Zeiss Ibas 2) was used to analyze the replicas.
Main Results:
- Morphometric computerized analysis demonstrated high sensitivity in quantifying skin atrophy.
- Results from computerized analysis showed a strong correlation with subjective visual examinations.
- The method successfully differentiated between the effects of mid-potency and high-potency topical corticosteroids.
Conclusions:
- Computerized morphometric analysis provides a sensitive and objective method for quantifying skin atrophy.
- This technique offers a reliable alternative to subjective assessments in dermatological studies.
- The method facilitates objective differentiation of topical corticosteroid potency, supporting clinical decision-making.