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Transcutaneous CO2 and O2 diffusion

E Berardesca1, H Maibach

  • 1Department of Dermatology, University of Pavia, Policlinico S. Matteo, Italy.

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1993
PubMed
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Transcutaneous gas measurements non-invasively monitor skin function but are limited by variables. Standardizing techniques and methods will improve this valuable research approach in dermatology.

Area of Science:

  • Dermatology
  • Physiology

Background:

  • Transcutaneous gas measurements provide a non-invasive method for assessing skin function.
  • Current techniques are limited by various factors affecting accuracy and reliability in clinical and research settings.

Purpose of the Study:

  • To review the factors influencing transcutaneous gas measurements.
  • To highlight the potential for improving these techniques in dermatological research.

Main Methods:

  • Review of existing literature on transcutaneous gas measurement techniques.
  • Analysis of physiological and environmental variables impacting gas flux.

Main Results:

  • Key variables affecting transcutaneous gas measurements include skin thickness, stratum corneum integrity, barrier function, vascular reactivity, arterial gas levels, and temperature.

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  • These factors significantly influence the accuracy of non-invasive skin monitoring.

    • Conclusions:

    • Transcutaneous gas measurements are a valuable tool for non-invasive skin assessment.
    • Standardization of methods and operator guidelines are crucial for enhancing the utility of this research approach in dermatology.