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Thyroid function in bulimia nervosa

A R Spalter1, H E Gwirtsman, M A Demitrack

  • 1Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, Maryland.

Biological Psychiatry
|March 15, 1993
PubMed
Summary
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This study found that bulimia nervosa patients have altered thyroid function, with triiodothyronine (T3) levels decreasing after abstinence from binge-purge behaviors. Caloric intake impacts T3 levels in these patients.

Area of Science:

  • Endocrinology
  • Psychiatry
  • Metabolic Disorders

Background:

  • Bulimia nervosa involves binge eating and purging, often associated with altered metabolic rate.
  • Thyroid hormones significantly influence metabolic rate, but their role in bulimia nervosa is debated.
  • Previous studies present conflicting data on thyroid function in patients with bulimia nervosa.

Purpose of the Study:

  • To investigate thyroid function in patients with bulimia nervosa.
  • To clarify the relationship between thyroid indices and metabolic rate in this population.
  • To examine changes in thyroid function during abstinence from binge-purge behaviors.

Main Methods:

  • Thyroid indices (T3, thyroxine, thyrotropin) were measured in 18 patients with bulimia nervosa at admission and after 3 weeks of abstinence.

Related Experiment Videos

  • Thyroid indices were compared between patients and 28 control subjects.
  • Correlations between thyroid indices and nutritional intake/body weight were analyzed at abstinence.

    • Main Results:

    • Patients with bulimia nervosa had normal thyroid indices at admission, with slightly lower triiodothyronine (T3) compared to controls.
    • After 3 weeks of abstinence, significant decreases in T3 and thyroxine, and an increase in thyrotropin were observed.
    • Abstinence T3 levels correlated positively with caloric and macronutrient intake and inversely with body weight percentage.

    Conclusions:

    • Binge-purge behaviors in bulimia nervosa may temporarily elevate thyroid indices and metabolic rate.
    • Reduced T3 levels after abstinence could be due to decreased caloric intake or hypothalamic-pituitary dysfunction.
    • Thyroid function and metabolic rate regulation are complex in bulimia nervosa.