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Depersonalization after marijuana smoking

R J Mathew1, W H Wilson, D Humphreys

  • 1Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.

Biological Psychiatry
|March 15, 1993
PubMed
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Marijuana smoking significantly increases depersonalization and alters time perception in healthy adults. Temporal disintegration was the strongest predictor of these marijuana-induced effects.

Area of Science:

  • Psychopharmacology
  • Neuroscience
  • Human Behavior

Background:

  • Depersonalization is a dissociative symptom characterized by detachment from oneself.
  • Understanding the acute effects of cannabis on psychological and physiological states is crucial.

Purpose of the Study:

  • To investigate the effects of high- and low-potency marijuana on depersonalization and other behavioral/physiological measures.
  • To identify predictors of marijuana-induced depersonalization.

Main Methods:

  • Double-blind, placebo-controlled study with 35 healthy volunteers.
  • Monitoring of behavioral and physiological indices before and after smoking marijuana or placebo.
  • Three laboratory visits separated by at least 1 week.

Related Experiment Videos

Main Results:

  • Marijuana smoking, unlike placebo, induced significant depersonalization, peaking 30 minutes after high-potency use.
  • Other effects included altered time sense, euphoria, anxiety, tension, anger, and confusion.
  • Physiological changes included increased respiration, pulse rate, and systolic blood pressure.

Conclusions:

  • Acute marijuana use is associated with depersonalization and altered sensory experiences in healthy individuals.
  • Temporal disintegration is a key factor predicting the severity of depersonalization.
  • Findings highlight the psychoactive and physiological impact of cannabis.