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A novel non-ataxic guinea pig strain with cerebrocortical and cerebellar abnormalities
V Lev-Ram1, M Valsamis, E Masliah
1Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093.
Brain Research
|March 26, 1993
Abstract:
This is the first description of GS guinea pigs, a partially inbred, non-ataxic, albino Peruvian (long-hair) strain with abnormal motor behavior and seizures. GS guinea pigs show gross and microscopic cerebellar and microscopic cerebrocortical abnormalities compared to Hartley strain animals. There is little difference between GS and short-hair guinea pig strains in Purkinje cell function, electrically evoked Ca2+ transients or immune responsiveness. The GS strain may prove useful in studying altered functions of the cerebellum in human disease.