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In situ lung perfusion with cisplatin. An experimental study
G B Ratto1, M Esposito, A Leprini
1Department of Patologia Chirurgica, University of Genoa, Italy.
Cancer
|May 15, 1993
Summary
In situ lung perfusion effectively delivers chemotherapy to the lungs, minimizing systemic exposure and offering a promising regional administration method for pulmonary metastases. This technique shows potential for targeted cancer treatment.
Area of Science:
- Pharmacology
- Oncology
- Surgical Techniques
Background:
- Evaluating in situ lung perfusion for regional chemotherapy delivery.
- Assessing the pharmacokinetic profile of cisplatin administered via lung perfusion.
Purpose of the Study:
- To evaluate the efficacy and safety of in situ lung perfusion for regional chemotherapy administration.
- To compare platinum levels in systemic and regional compartments using different cisplatin delivery methods.
Main Methods:
- Cisplatin administration in pigs using stop-flow and lung perfusion techniques.
- Serial blood and tissue sampling for platinum concentration analysis.
- Histopathological examination of lung tissue and assessment of gas exchange.
Main Results:
- Lung perfusion resulted in lower systemic and higher regional platinum levels compared to stop-flow.
- No significant difference in platinum exposure between stop-flow/out-flow occlusion and lung perfusion.
- Mediastinal node platinum levels were higher, and bone marrow levels lower with lung perfusion.
Conclusions:
- In situ lung perfusion provides a pharmacokinetic rationale for treating pulmonary metastases.
- This regional chemotherapy delivery method shows potential for improved drug targeting to the lungs.