Related Experiment Videos
Myxopapillary ependymoma. Results of nucleolar organizing region staining
D A Ross1, P E McKeever, H M Sandler
1Section of Neurological Surgery, University of Michigan Medical Center, Ann Arbor 48102.
Background:
Although myxopapillary ependymomas are generally benign with a tendency for slow growth and local recurrence, they are capable of spread within the nervous system and of extraneural metastasis. Histologic features have not been helpful in determining which patients are at risk for recurrence or dissemination, making management decisions difficult.
Methods:
A retrospective review was conducted of 14 cases of myxopapillary ependymoma. The nucleolar organizing region (NOR) staining method was used to determine if this technique was useful in the management of these tumors.
Results:
Five patients had total resections of encapsulated lesions, four had total resections of adherent tumors, and four had subtotal resections. Twelve received postoperative radiation therapy. With a mean follow-up of 80 months, 12 patients are well and disease-free. Two patients have had recurrences after surgery and irradiation, leading to death in one and disability in the other. The mean number of NOR per cell in eight specimens ranged from 0.4-1.64. The patient who died with intracranial spread had the highest number of NOR per cell.
Conclusions:
Based on these data and a review of the literature, it is recommended that radiation be delayed until recurrence in tumors that have been totally resected. Local radiation therapy may be indicated in subtotally resected tumors. NOR staining shows promise in predicting the likelihood of spread of tumor. Patients with myxopapillary ependymomas should be followed indefinitely because of the potential for late recurrence, even after aggressive therapy.
Insights
Myxopapillary ependymomas can spread despite being benign. Nucleolar organizing region (NOR) staining may predict tumor spread, guiding treatment decisions for better patient outcomes.
Area of Science:
- Neuro-oncology
- Surgical Pathology
Background:
- Myxopapillary ependymomas are typically benign but can metastasize.
- Histologic features do not reliably predict recurrence or spread.
- Management decisions are challenging due to unpredictable behavior.
Purpose of the Study:
- To evaluate the utility of nucleolar organizing region (NOR) staining in predicting myxopapillary ependymoma behavior.
- To assess outcomes following different treatment strategies.
Main Methods:
- Retrospective review of 14 myxopapillary ependymoma cases.
- Analysis of nucleolar organizing region (NOR) staining in tumor specimens.
- Correlation of NOR staining with clinical outcomes and treatment response.
Main Results:
- Most patients (12/14) were disease-free after surgery and radiation.
- Two patients experienced recurrence, with one fatality and one disability.
- NOR staining showed a range of 0.4-1.64 NOR per cell.
- The patient with fatal intracranial spread had the highest NOR count.
Conclusions:
- Delaying radiation until recurrence is recommended for totally resected tumors.
- Local radiation therapy may be beneficial for subtotally resected tumors.
- NOR staining shows potential for predicting tumor spread risk.
- Indefinite follow-up is crucial due to the risk of late recurrences.